How would you treat a patient with Hodgkin lymphoma who has an isolated relapse within the CNS?

It's challenging to offer specific advice in this situation without knowing a lot more. First, it's important to recognize that CNS involvement by classical Hodgkin lymphoma is extremely rare and strictly requires a brain biopsy to make a diagnosis (even in a patient with active systemic CHL, a seco...

I agree that a CNS biopsy would be essential. If relapse is truly restricted to CNS then ICE would be an option as might stereotactic radiation therapy.