How would you treat a patient with metastatic NSCLC on pembrolizumab with a sustained complete response, now with 2 isolated small liver lesions?

Topics: Thoracic Malignancies • Medical Oncology • NCI-CCC Tumor Board Question • Ohio State University

Would you treated with local therapies (RFA or SRS) and continue pembrolizumab or would you move to second line treatment?

Answer from: Medical Oncologist at Academic Institution

I am unaware of any "level 1" evidence for this approach, much of our data is anecdotal, however there is certainly reasonable experience of treating "oligo-progressive" disease with local therapies. While there is more experience in adrenal and CNS metastatic disease, I would think that a loc...

Comments

Medical Oncologist at St Louis Cancer Care LLP
FYI, supporting evidence for this approach, i.e., ...

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