How would you treat a pregnant woman in the third trimester with locally advanced, hormone receptor positive, HER2 positive breast cancer?
Would you maintain dose density of chemotherapy and use peg-filgrastim prior to delivery of the baby? Would you defer taxane and anti-HER2 therapy until after delivery of the baby?
2 Answers
Mednet MemberInvited Expert
Medical Oncology · Yale
Answered on
Given good amount of safety data on anthracycline therapy during pregnancy, favor doxorubicin cyclophosphamide x 3-4 cycles (depending on time of delivery) given every 3 weeks without peg-filgrastim support. With less data with growth factor support, lean toward avoiding in this situation. Will avoi...
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Mednet Member
Medical Oncology · University of Iowa Holden Comprehensive Cancer Center
Answered on · Updated on
I would say, FAC regimen (5-fluorouracil, Adriamycin and Cyclophosphamide) has one of the best data during 2nd/3rd trimester based on MD Anderson's prospective cohort published data
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