How would you treat a pregnant woman in the third trimester with locally advanced, hormone receptor positive, HER2 positive breast cancer?

Topics: Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Ohio State University

Would you maintain dose density of chemotherapy and use peg-filgrastim prior to delivery of the baby? Would you defer taxane and anti-HER2 therapy until after delivery of the baby?

Answer from: Medical Oncologist at Academic Institution

Given good amount of safety data on anthracycline therapy during pregnancy, favor doxorubicin cyclophosphamide x 3-4 cycles (depending on time of delivery) given every 3 weeks without peg-filgrastim support. With less data with growth factor support, lean toward avoiding in this situation. Will avoi...

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Medical Oncologist at Warren Alpert Medical School of Brown University
While I generally prefer non-anthracycline regimen...

Answer from: Medical Oncologist at Community Practice

I would say, FAC regimen (5-fluorouracil, Adriamycin and Cyclophosphamide) has one of the best data during 2nd/3rd trimester based on MD Anderson's prospective cohort published dataHahn KM, Johnson PH, Gordon N, et al. Treatment of pregnant breast cancer patients and outcomes of children exposed to ...

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