How would you treat a relatively focal but multinodular staple line recurrence of non-mutated lung adenocarcinoma s/p margin-negative lobectomy?

It depends on how multinodular and how far apart the nodules are. If the total PTV is reasonable and dose constraints can be reasonably reached with SBRT, then I would generally prefer to proceed with SBRT. If SBRT is not feasible, then hypofractionated RT versus conventionally fractionated chemo-RT...