How would you treat DLBCL of the terminal ileum in an otherwise healthy patient?

Primary intestinal Diffuse large B cell lymphoma (PI-DLBCL), even if found incidentally on a screening colonoscopy in an asymptomatic patient, should be treated with systemic chemotherapy similar to what is done with nodal DLBCL. With this approach, the prognosis for PI-DLBCL is very good based on two retrospective studies.

A report of patients with B cell primary intestinal lymphomas (PI-L) included 91 patients, 38 of whom had DLBCL (Matysiak-Budnik et al. Digestive and Liver Disease volume 45; ...