How would you treat psychotic symptoms in a patient with atypical psychotic-induced leukopenia with absolute neutrophil count (ANC) below 500 cells/µL (<0.5 x 10^9 L)?

I have not been faced with that situation except on Clozaril. I will use benzodiazepines initially to control anxiety and reduce the stress with psychotic symptoms. Later, when the white count starts to improve, I will initiate a different drug. Will go slow and check counts often enough not to miss...

The safest one to replace an antipsychotic will be haloperidol and lurasidone.

Diagnosis? Age? BMI?

These are things I always take into account, but not having any details, I would say Haldol and lithium.

Also, see if there is any BEN.