If a patient is noted to have multiple PIRADS-4 and PIRAD-5 lesions of the prostate on MRI, do you offer simultaneous integrated boost via FLAME?

It is a reasonable approach to boost multiple lesions. The FLAME protocol allowed for the treatment of multiple GTVs as long as dose constraints could be maintained. These investigators published a separate paper evaluating the contouring on the trial and reported a maximum of 5 lesions boosted in a...