If a patient is unable to tolerate one CDK 4/6 inhibitor, do you switch to a different one?
For example, a patient has had multiple dose reductions for neutropenia and required an admission for infection while on palbociclib. Would you switch to abemaciclib?
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If a patient is unable to tolerate one CDK 4/6 inhibitor, do you switch to a different one?
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3 Answers
Mednet MemberInvited Expert
Medical Oncology · Winship Cancer Institute and Emory University School of Medicine
Answered on
There are currently no data about switching from one CDK 4/6 inhibitor to another. The current recommendations for palbociclib with grade 3 neutropenia and infection are to hold palbociclib until recovery to grade 2 or less and then dose reduce. It sounds as though this patient has required multiple...
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Mednet MemberInvited Expert
Medical Oncology · University of Utah Huntsman Cancer Institute
Answered on
I agree. I have had success switching from palbociclib to abemaciclib for patients with neutropenia, and from one CDK4/6 inhibitor to another for a patient with cutaneous toxicity.
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Mednet Member
Medical Oncology · Onc-Hem Assoc PA
Answered on
Yes
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