If a patient on ovarian suppression with goserelin for ER+HER2- BC achieves post-menopausal-range estradiol levels but does not achieve post-menopausal FSH levels, is she suppressed?

Topics: Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • UCLA

Patient has hot flashes.

Answer from: Medical Oncologist at Academic Institution

Per the package insert and thinking about the mechanism of action with goserelin, FSH levels should be suppressed to follicular phase levels. This usually occurs within four weeks after initial administration of drug and remains in this range. This needs to be kept in mind when following FSH l...

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Medical Oncologist at Medical College of Wisconsin
The drug levels (goserelin and others) usually see...

Answer from: Medical Oncologist at Community Practice

Yes, goserelin most likely suppressed the ovarian function based on hot flashes. It is a super rare that goserlin does not work after 4 weeks. FSH is expected to go down with goserelin. After two to four weeks, after the surge, pituitary gland shuts down. Technically, measuring the FSH or estradiol ...

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Medical Oncologist at Mayo Clinic Rochester
Change in FSH to goserilin can depend on how far i...

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