If using protons instead of photons, does the use of protons impact your recommendation for using hypofractionation in breast cancer?

I work at Mayo in Rochester, and we have a busy proton breast practice. We routinely use moderate hypofractionation for non-reconstructed or intact breast patients treated with protons. We also have initiated and enrolled a number of patients on hypofractionation trials with our Arizona colleagues, ...

We have been using the Canadian hypofractionated RT regimen for whole breast at our proton center since 2016 when indicated. We typically modulate the dose 5 mm off the skin (100% IDL 5 mm in). In general, have not noticed any major difference in skin side effects with this approach compared to phot...

No, it does not. We have offered hypofrac routinely to women with unreconstructed chest wall or intact breast who are recommended for proton therapy, need RNI, and not participating in RADCOMP. We most often use the UK START B 40 Gy/15 fractions.

We continue to recommend patients participate on the R...