In 2024, do you consider isolated gain(1q) [not amp(1q)] to be a high-risk cytogenetic abnormality in multiple myeloma?
Most would argue that gain(1q) in combination with another high-risk feature constitutes ultra-high-risk multiple myeloma, and most would argue (with FORTE being a good example) that amp(1q) is a high-risk feature. What about patients who have exactly 3 copies of 1q and no other high-risk features?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Chicago
Answered on
The brief answer from my standpoint is that some patients with 1q gain will have their disease behave high-risk and some will not.
The longer answer...
As the question alludes to, the presence of high-risk cytogenetic abnormalities and 1q gain should be considered high-risk (or even ultra high-risk)....
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