In a patient with metastatic prostate cancer on abiraterone planning to start Radium-223, what is the minimum interval between the last dose of abiraterone and the first dose of Radium?

Update, May 16, 2026.

The context of the question changes based on recently published data. These include the safety of combining an androgen receptor pathway inhibitor (ARPI) with Ra-223 and the utility of this approach in the evolving practice of metastatic prostate cancer.

Abiraterone has a half-l...

In-vivo studies have shown abiraterone is rapidly absorbed after oral intake and bioavailability is <10% in fasting state. Abiraterone has a half-life of 12-24 hours and if the dose is not repeated, most of the administered drug should be eliminated within a few days. Based on this, I do not see any...