In a patient with Type I von Willebrand disease with history of VTE and heavy menses, would tranexamic acid be a treatment option?

No, with thrombosis one would not inhibit the thrombolytic pathway. Would anticoagulate with Coumadin with low INR 1.5 to 2.

I think it would depend on the history regarding the VTE. If it occurred in the setting of a strong provoking factor which has since been resolved, her VTE risk now may be minimal. Based on your question, she has already tried OCPs without benefit (and presumably without recurrent VTE). As long as s...

Why not try hormonal IUD or implant as long as the patient is willing to try (as almost no risk of thrombosis)?