In a premenopausal HR+ patient with pT2 pN0(i+) disease and RS<16, does the presence of isolated lymph node tumor cells affect your decision to avoid chemotherapy?
Oncotype score in this case was 14.
Answer from: Medical Oncologist at Academic Institution
No, I would consider this node negative disease, aligning with the AJCC staging. I would recommend no chemotherapy for a RS of <16 in a premenopausal woman based on the results from TAILORx, which indicated no benefit from chemotherapy in those with low recurrence scores.