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In AIH/PBC overlap with both hepatitis and cholestasis, how do you determine whether incomplete biochemical response at 6–12 months reflects undertreated AIH versus inadequately controlled cholestasis?

How do you escalate therapy accordingly?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Hepatology · University Of Colorado Hospital Authority
Answered on

Overlap can be very challenging to treat. In this situation, it is reasonable to perform a repeat liver biopsy. If autoimmune hepatitis remains active, it would increase the IS.

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