In light of the improved outcomes seen in patients receiving IO +/- olaparib, what role, if any, do you think pelvic radiation still plays in the management of patients with advanced endometrial cancer?

The study included a wide spectrum of patients including advance stage with residual disease or recurrent with or without residual disease. Prior RT when indicated was allowed and about 40% had RT as part of care.

The standard of care for metastatic endometrial cancer is systemic therapy with chemotherapy and now with or without immunotherapy. The role of radiation therapy may be individualized to a patient's specific clinical situation for improved "local" control.

Following the final overall survival results from GOG 258 which failed to show a survival benefit with adjuvant chemoradiotherapy vs chemotherapy alone, pelvic radiation in the upfront management of patients with advanced endometrial cancer should not be used routinely. In a subsequent exploratory a...