In locally advanced rectal cancer treated with total neoadjuvant therapy, do you adjust boost volumes to only include post-chemo gross disease/nodes plus a margin?

The answer to this question is that there is usually no risk reduction advantage to making the boost volume smaller for the last 5.4Gy. it may be better to make the boost volumes larger than a uniform expansion on the GTV.

There is no definitive guide to boost volumes in rectal cancer. We published o...