In patients who develop a VTE, what conditions do you consider as persistent, provoking risk factors, and at what point are they controlled enough to stop anticoagulation?

Not a lot of controlled trials that address each situation so we rely on expert consensus and judgement, and more importantly, balancing the risk of hemorrhage vs thrombosis. ASH guidelines define chronic persistent risk factors as 1) Active cancer (e.g., ongoing chemotherapy; recurrent or progressive disease); 2) Inflammatory bowel disease (IBD); 3) Autoimmune disorders (e.g., antiphospholipid syndrome, rheumatoid arthritis); 4) Chronic infections; 5) Chronic immobility (e.g., spinal cord injury). [Ortel et al., PMID 33007077]. However, each situation is nuanced and requires a balanced view. One example is in IBD, a patient has had total colectomy and has 'quiescent' IBD, however, the underlying inflammatory component is most likely active...