In patients with breast cancer and concern for bone-only metastases on imaging but with non-diagnostic IR biopsies, do you pursue surgical bone resection for diagnosis or treat empirically for metastatic disease based on pathology from breast lesion?
Answer from: Medical Oncologist at Academic Institution
The preferred approach would be to have confirmed tissue diagnosis and receptors repeated on the metastatic lesion, so if feasible/accessible, I would pursue that prior to treatment. If risks of biopsy outweigh benefits then treating empirically based on pathology from primary lesion sounds reasonab...
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