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In patients with microscopic colitis, what do you recommend on stopping SSRIs?

What alternatives do you recommend?
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Which of the followwing drug classes do you discontinue or switch for microscopic colitis patients?

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1 Answer
Mednet Member
Mednet MemberInvited Expert
Gastroenterology · Icahn School of Medicine at Mount Sinai
Answered on

First, make sure the problem is not NSAIDs, PPIs, or statins.

Second, remember that the evidence linking SSRIs to microscopic colitis is not iron-clad.

Third, if you want to do a trial of a different class of antidepressant, the evidence linking SNRIs to microscopic colitis is even less consistent.

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