In patients with severe osteoarthritis, can elevated alkaline phosphatase levels be attributed to increased bone turnover from advanced joint degeneration?

Answer from: at Academic Institution

Unlikely. Other potential sources require investigation. At the very least, explore alk phos fractions/isotopes, parathormone and vitamin D levels.

Comments

at UTMB Health
And if very elevated, rule out Paget's.

Answer from: at Academic Institution

Good point, but should be obvious on x-ray...

Comments

at UTMB Health
Yes, if several bone areas are x-rayed, not just t...