In refractory germ cell tumor, in the absence of results of the randomized TIGER trial, how do you determine if patients should be treated with conventional-dose chemotherapy versus high-dose chemotherapy?

Many germ cell tumor experts including myself believe that the important questions asked by TIGER trial are already sufficiently answered and the impact of the trial is likely to at the very least be low.

A number of germ cell tumor expert centers have chosen not to participate in the TIGER trial be...