In suspected PBC–autoimmune hepatitis overlap, how do you sequence immunosuppression versus escalation of PBC-directed therapy when ALP remains elevated at 6 months but bilirubin is normal?
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Would your next step be to start a PPAR agonist?
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Hepatology · Mount Sinai Hospital
Answered on
Assuming the autoimmune hepatitis is under control with normal ALT and AST, if the ALP is still elevated and maybe the GGT as well, then it would be time to add a PPAR. Personally, I start with seladelpar but Elafibranor works just as well and both continue to work for many months continuously norma...
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