In what clinical scenario, if any, would you consider APBI appropriate treatment for a patient with triple-negative breast cancer?
Would you consider APBI for an ER/PR/HER2 negative pT1-2 N0 with pathologic complete response after neoadjuvant chemotherapy?
Would the presence of breast augmentation with implants move the risk-benefit ratio in favor of APBI?
NSABP 39 included 19% on each arm where ER/PR was negative
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Would you consider APBI appropriate treatment for a patient with TNBC who otherwise fits criteria for B39?
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2 Answers
Mednet MemberInvited Expert
Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on
Currently, none of the prospective studies did APBI after neoadjuvant chemotherapy so that subset, we don't offer APBI (need studies in this space).
As far as denovo early-stage TNBC, we have not been doing APBI as were only part of one (B39) of all prospective randomized studies with PBI and also sh...
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Mednet MemberInvited Expert
Radiation Oncology · Abramson Cancer Center, University of Pennsylvania
Answered on · Updated on
Agree regarding PBI after NAC with @Dr. First Last.
We only offer whole breast radiation after neoadjuvant therapy for TNBC. Although, I suspect it’s one of these ‘it might be fine’ things, but we still won’t do it.
But we have chosen to offer PBI for small ER negative disease who have received approp...
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