In what clinical scenario would you consider liver transplant evaluation for a patient with sickle cell hepatopathy?

We have evaluated and transplanted patients with sickle cell hepatopathy with severe liver dysfunction but well-controlled sickle cell. These patients will typically have jaundice, coagulopathy, and biliary strictures. They should not have significant extrahepatic complications of the hematologic disease. Having very close follow-up from the sickle cell team is absolutely critical. I don't think a BM transplant is always necessary, but it can be considered once the patient has recovered and stab...

I would do a concurrent stem cell transplant - in an effort to cure the underlying problem of sickle cell disease. Ideally, the same donor to prevent graft rejection.