In what scenarios do you consider using an amniotic membrane graft for macular hole closure?

Given that the success rate of closing macular holes is excellent when the hole is worth closing, and that there are no studies demonstrating the benefit to the patient of amniotic membranes for (presumably) very large and chronic holes, I can't recommend this approach. Having said that, I have no experience, as I do not see the value. Even large holes that are borderline in being surgical candidates can usually be closed with an ILM flap, and if you want to close a huge > 1500 u hole for whatev...