In what setting would you omit neoadjuvant radiation in favor of neoadjuvant chemotherapy alone for a T3N0 upper rectal adenocarcinoma?

The benefit of radiation for clinically staged T3N0 upper rectal cancers is unclear. Overall, the benefits of neoadjuvant radiation seem to be for lower rectal cancers. The main concern, in this case, is that clinical staging may underestimate pathological staging, as benefit from (neo)adjuvant radi...