In what situations would you recommend metformin in addition to aggressive lifestyle interventions for patients with prediabetes and obesity?
So based on studies such as the Diabetes Prevention Program and newer meta-analyses such as Comparison of the Efficacy of Metformin and Lifestyle Modification for the Primary Prevention of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials (Vajje et al., PMID 38021728). Lifestyle modification is just as effective, if not somewhat more effective, at preventing progression to diabetes. So if someone is willing to do aggressive lifestyle modification, I almost never prescribe metformin for diabetes management. However, Metformin is off-label use for weight loss, and many patients do have a decent amount of weight loss with the addition of metformin, so for someone who is interested in weight loss on top of lifestyle modification ...
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