In your clinical practice, how are you approaching consideration of limbic-predominant age-related TDP-43 encephalopathy (LATE) in the differential diagnosis for older adults previously thought to have Alzheimer's disease?

At the moment, I am not finding that this diagnosis is extremely helpful. In general, LATE looks for all the world like AD at the time of diagnosis in the oldest patients, but it doesn't progress like we expect it to. LATE, by itself, seems to be a much more slowly progressive disease. So I find mys...

I consider LATE in almost all older patients in late life (>85) when they present to me with cognitive changes.

I agree, biomarkers are necessary for a more precise diagnosis. But clinical history of slow progression and reasonably well-maintained functional status clues towards LATE rather than AD....