In your experience how does the dose of Remeron (mirtazapine) influence side effects like hunger and weight gain?

Mirtazapine will have a more severe occupancy on histamine receptors at the lower doses. That is why we use 7.5 mg as a hypnotic. As you increase the dose, there is also more norepinephrine being produced.

I couldn't put hard numbers to this, but I think that higher doses of mirtazapine are more likely to result in weight gain and sedation.

I agree with both the clinical experience and theoretical answers above. That is, lower dose remeron is sedating (The first patient I ever prescribed it to, probably at 15 mg hs, said she slept all weekend with one dose.) Higher doses produce more sedation, although perhaps not as much per mg, and b...