Is 2 Gy x 2 (or the "boom boom" regimen) appropriate for treating patients with low volume stage I MALT lymphoma?

I disagree. My answer is no. The quoted series contains very few patients with short follow-up. I am not aware of any large series with long follow-up of MALT pts with early stage disease treated with curative intent in this fashion. A randomized trial of 2gy x 2 for early-stage follicular lymphoma ...

This question/ topic has generated a lot of interest with most respondents favoring the 2Gy x 2 approach, so I'm going to invoke a little backup. NCCN guidelines as well as International Lymphoma Radiation Oncology Group guidelines (Red J 92:15, 2015) and the previously cited FORT trial (Lancet Onco...

We did this often in training - so long as the patient was amenable to close follow up and understood that sometimes we would have to come back and do additional treatment. (For gastric primaries this was only done on protocol; as patients required repeat EGDs and biopsies.) We almost universally of...

I think it is appropriate in the well-informed, reliable patient with good follow-up (as is the case in any situation where salvage can make up for lesser initial treatment). The salient issues have already been discussed, but here are my two cents:

Generally speaking, this is an indolent disease tha...

A good conversation regarding dose for stage IAE MZL orbit presentations. Thoughtful perspectives that are defensible on both sides IMO. SOC is 24 Gy/12, with emerging data on 4 Gy/2. I'm sure we all have had patients with morbid long-term toxicities from 24 Gy, I certainly do - but this was primari...