Is angioedema secondary to IV tPA considered an absolute contraindication for tPA in future?
3 Answers
Mednet Member
Neurology · University of Calgary
In short, no. In general, the only absolute contraindications to alteplase and other forms of tPA are active bleeding or situations that could result in active uncontrollable bleeding; all other considerations are relative. Hemi-orolingual angioedema is thought to arise associated with activation of...
Mednet Member
Neurology · Memorial Hermann
From Bianca Pirlog MD and James Grotta MD; Houston Mobile Stroke Unit, Memorial Hermann Hospital, Houston, Texas.
As Dr. @Dr. First Last already mentioned, the angioedema post tPA seems to be associated with activation of the kallikrein system and it seems that patients under ACE inhibitors are at in...