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Is axitinib with concurrent spinal RT safe?

Is concurrent axitinib contraindicated if a patient is to be treated with conventionally-fractionated spinal RT (e.g., is not a candidate for spinal SBRT)?
1 Answer
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Radiation Oncology · Memorial Sloan Kettering Cancer Center
Answered on

We have always been cautious about giving axitinib concurrently with CNS radiotherapy. There is pre clinical data suggesting radiosensitization with high dose single fraction radiation due to VEGF effects on the endothelium (Rao et a., PMID 24794795.) Out of an abundance of caution, we typically sto...

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