Is history of radiation therapy for uterine cancer an absolute contraindication to parathyroid hormone/parathyroid hormone related protein analogues such as teriparatide and abaloparatide in a patient with severe osteoporosis with multiple spine fractures?

I agree with Dr. @Dr. First Last. The initial studies in young rats given high doses of PTH compounds for most of their lifespan (I think until either 24 or 36 months of age) resulted in a higher-than-expected number of incident osteosarcomas. However, the black box warning about skeletal radiation ...

There is no doubt that the two approved PTH anabolic drugs increase osteosarcoma in rats. As part of the approval agreement for Forteo, Lilly embarked on a very well-planned post-marketing safety study looking at patients with osteosarcoma and a prospective study with patients starting Forteo.

This...