Topics:
Radiation Oncology • Gastrointestinal Cancers
Is it acceptable to deliver ablative hypofractionated radiation therapy for unresectable intrahepatic cholangiocarcoma in conjunction with concurrent checkpoint inhibitor?
Would you be concerned with more and higher grade hepatobiliary toxicity with concurrent use of checkpoint inhibitors (i.e. Keytruda)?
Answer from: Radiation Oncologist at Academic Institution
There are safety data from MGH with single agent checkpoint inhibition (from @Theodore S. Hong) that demonstrate the combination is safe. The only concern I would have would be if you were starting both at the same time and the TAAs started to rise. You would not be able to discern toxicity from the...
Sign in or Register to read more