Is it appropriate to consider ultra-hypofractionation for phyllodes tumors of the breast when adjuvant radiotherapy is indicated?

I have used moderate hypofractionation for patients with phyllodes tumors for whom the logistics of coming for conventional fractionation were too great. However, I agree with Dr. @Dr. First Last that there are no data yet supporting this for phyllodes tumors specifically. Further, the issue of whether moderate hypofractionation is effective is controversial among sarcoma experts - see the review by Guadagnolo and Baldini, PMID 38508783.

There is no evidence supporting even moderate hypofractionation for these patients. That is not to say that it would not be effective, but these patients have never been studied.

This is one of the only groups of breast patients I still treat with 2.0 Gy/Fx in 2025.

It's a different histology, sort of sarcoma-ish, and would stick to 50-60 in 25 to 30 fx, depending on whether boost is indicated.