Is it ever appropriate to initiate a higher initial dose of allopurinol (such as 300mg daily) than is typically recommended in gout patients at low risk of allopurinol hypersensitivity syndrome and severe hyperuricemia?
Answer from: at Academic Institution
Usually, allopurinol is started at a dose lower than that and gradually titrated up. This is the best strategy. In a rare instance, allopurinol may be started at 300 mg initial dose - where the patient has tolerated it at this or higher dose previously and is currently non-adherent; or has severe hy...
Sign in or Register to read more
Answer from: at Community Practice
We often start allopurinol at a 300mg/day dose in non-Asian gout patients who have an absence of renal impairment or other grave comorbid diseases. This shortens the often protracted ULT titration phase during which there is a higher propensity for gout attacks. For patients with stage III CKD...