Is it safe and/or necessary to combine osimertinib and carboplatin/paclixel for a patient with stage IV EGFR mutated NSCLC and advanced ovarian carcinoma?

This is a tough situation and a lot depends on the status and urgency of the ovarian cancer and whether surgery is planned for it. I would not combine the chemotherapy and osimertinib simultaneously for sure. There are several studies that show the combination of chemo and TKI is not as good as TKI ...