Topics:
Breast Cancer • Radiation Oncology
Is it safe to hypofractionate for whole breast RT in patients with a BRCA 1/2 or CHEK2 mutation to chose to have breast conservation for early stage breast cancer or DCIS?
Answer from: Radiation Oncologist at Academic Institution
There is no evidence that hypofractionation compared to conventional fractionation results in higher acute or long term toxicities in patients who have these mutations. Since a majority of these patients may also be in a younger age group many clinicians may appropriately feel uncomfortable in offer...
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Answer from: Radiation Oncologist at Academic Institution
I agree with @Bruce G. Haffty about the lack of evidence of increased toxicity in patients with BRCA1/2 or CHEK2 alterations (or PALB2 etc) and frequently refer to his important work in this area. In START B there were 108 women <= 39 and 457 women <= 49 randomized. One of the most striki...