Is it safe to use doses of 3Gy in a BID treatment for palliative urgent cases?

This combination of a "hypofractionationated" 3 Gy dose per fraction with a "hyperfractionated" BID schedule has been described in the setting of "quad shot" radiation- most typically associated with head and neck cancers. The goal is to provide robust palliation within a short time frame. The "quad...

Off the cuff re: lung cancer palliation I'd say "yes" it's safe to give 3 gray twice in one day. Because I know it's safe to give 8.5 Gy in one day as part of a 17 Gy palliative regimen (http://ascopubs.org/doi/full/10.1200/jco.2004.06.123). And I have done this rather often. And I have seen these "...