Is it safe to use medroxyprogesterone for vasomotor flushing?
If yes, what dosage and do you use it continuously or intermittently? Regarding provera, many patients with ER/PR (+) breast cancer worry about taking a drug that could interact with their progesterone receptor.
Answer from: Medical Oncologist at Academic Institution
There are many options for management of hot flashes including venflaxine and gabapentin being most frequently used as well as some data on cognitive behavioral therapy, oxybutynin, and acupuncture. For the most refractory cases, I do discuss medoroxyprogesterone 400 mg IM as a one time option base...
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Answer from: Medical Oncologist at Community Practice
One must remember that progesterone (Medroxyprogesterone acetate) is actually a treatment for metastatic ER+ Breast cancer. In addition, the Loprinzi study showed no adverse effects on breast cancer disease status.