Is post-mastectomy radiation required in patients with cT2N1 breast cancer who undergo neoadjuvant chemotherapy and are then found to have negative lymph nodes at the time of mastectomy?

This particular subset of patients has the most data suggesting that response to neoadjuvant chemotherapy can be used to tailor post-mastectomy radiation (PMRT) decisions. A retrospective study from MD Anderson (McGuire IJROBP 2007) evaluated 106 patients who received neoadjuvant chemotherapy and ac...