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Is tall cell variant papillary thyroid cancer automatically categorized as intermediate risk regardless of other histopathological features and should consequently be treated with RAI?

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Would you give RAI in tall cell variant PTC under 2 cm with clear margins and negative nodes?

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1 Answer
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Mednet MemberInvited Expert
Endocrinology · BMCWorking Well Occupational Health Clinic
Answered on

Tall cell PTC always has a BRAFV600E mutation and should automatically make the patient an ATA intermediate Initial Risk. But not all intermediate risk patients should get RAI RX. With small tumors, no ETE, no nodes AND if the 6 week postop Tg is < 1, I would do "delayed therapy" with "watchful wait...

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