Is there a current 'standard of care' dose and fractionation in treating lung cancer with SBRT?
We have previously discussed the right BED dose equivalence for SBRT; one of the questions that is posed is which schema is "standard"? There is no one single standard scheme. We recommend that as an institution, you develop a process and scheme that works within your structure and workflow; we tend...
I agree with @Dr. First Last that the most compelling clinical evidence we have for radiation dose for lung SBRT is based on datasets reporting BED for various regimens. 2 datasets, published by Onishi et al. and Grills et al., respectively, show that local control is optimized if the BED is greater...
An interesting caveat to keep in mind is that not every group defines the prescription the same way. For example, the Japanese early experience as described in Onishi often prescribed the dose to the isocenter. The dose given to the edge of a PTV is, then, on the order of 90% of that depending on tu...
Currently, there are a number of different fractionation regimens that are "standard". I think tumor size and location may play into potential variations of dose fractionation schemes. I have successfully used 60 Gy in 3 fractions, 48 Gy in 4 fractions, and 50 Gy in 5 fractions. I am anxious to see ...