Is there a maximum ifosfamide cumulative dose in patients with normal kidney function?

Topics: Pediatric Oncology • Ewing Sarcoma • Osteosarcoma

When offering ifosfamide / etoposide for relapsed osteosarcoma, patient is being given 2.8mg/m2 of ifosfamide. Is 6-8 cycles exceeding any known lifetime dose limit? The increased number of cycles are given in the setting of high risk relapse (early/multifocal), after aggressive surgery, and having tolerated the first few cycles well.

Answer from: at Academic Institution

Here are a number of references from osteosarcoma as well as rhabdo patients. There is no "lifetime limit" but the more you give the higher the risk of renal Fanconis or other renal dysfunction. 72 g/m2 is generally well-tolerated, but not in everyone. There is also no data comparing 14 g/m2/cycle t...

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at FibroFighters Foundation
Thank you!! Very helpful!!

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