Is there a role for adjuvant chemotherapy in a young healthy patient with a large malignant phyllodes tumor of the breast with positive margins?  

I think we first need to know how we are addressing the R1 or R2 resection. If we are not doing more surgery or radiation for the positive margin, then this is an unresectable disease and will benefit from systemic therapy.

The multidisciplinary team needs to discuss the possibility of getting negative margins and pre-/post- op XRT for improved LC as part of SOC. The topic of adjuvant therapy for STS remains an area of debate. Proponents are convinced of the benefit in high-risk (Sarculator risk >60%) in extremity/s...

By far, the most important thing is to achieve wide negative margins, with cautious consideration of any adjuvant therapy (radiation and/or chemo). Here at Duke, our phyllodes expert breast surgeon, Dr. Laura Rosenberger, frequently recommends/performs completion mastectomies, and we have a multidis...

Yes, I agree. Best to have clear margins first.