Topics:
Genitourinary Cancers • Bladder Cancer • Medical Oncology • Immunotherapy • ASCO Journal Club
Is there a role for DDR gene mutation or tumor mutation burden/load in predicting response to immunotherapy in urothelial cancer?
Answer from: Medical Oncologist at Academic Institution
Our recent work showed that urothelial cancers harbor high rate of alterations in DDR (DNA damage repair and response) genes, with 25 – 29% rate of deleterious alterations and up to 25% with variants of unknown significance – considering the genomic complexity of ...
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