Is there a role for eculizumab in the management of refractory lupus nephritis?
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3 Answers
Mednet Member
Nephrology · King Abdul-Aziz Medical City, Ministry of National Guards Health Affairs
There is no evidence of eculizumab as a treatment for lupus nephritis, yet it might be considered if complement-mediated TMA presents even as a result of SLE as a trigger if direct treatment of SLE fails to achieve clinical goals.
Mednet Member
Nephrology · Ohio State Department Of Nephrology
This is currently being evaluated. There is a study of ravulizumab in patients with lupus nephritis or IgA nephropathy (basket trial).
Mednet Member
Nephrology · Rush Medical College
A couple of older references. I think you HAVE to think outside of the box when you have refractory ANYTHING. My opinion...