Would you be comfortable combining rituximab with voclosporin in patients with lupus nephritis not responding to standard therapy?

1st: Voclosporin is standard therapy :-). I find it interesting that we often use "standard therapy" to mean "a mycophenolate analogue or cyclophosphamide (CYC)." I consider these "old therapies" that only achieve a 25% to 30% clinical remission, leaving 65% - 70% of those patients at high risk of e...

I agree with Dr. @Dr. First Last' comments. I think we can use the combination of a CNI and a B-cell depleting agent safely, and this has been reported, as noted, in non-lupus membranous nephropathy. In LN, the combination of a T cell drug and a B cell drug may provide a synergistic approach to trea...