The great majority of lymphoproliferative disorders of the orbit turn out to be NHL when subjected to sophisticated pathologic evaluation, but even those which are considered benign lymphoid hyperplasia (LH) are often and successfully treated with radiotherapy. The dose of RT for low-grade lymp...

When I don't have pathology/flow/PCR reports diagnostic of malignancy, I have treated patients with "lymphoid atypia", "atypical lymphoid infiltrate", or "lymphoproliferative disorder" with symptomatic disease to 4 Gy in 2 fractions. I have a collection of such patients (about a dozen), almost all o...

To confirm the diagnosis of orbital lesion, biopsy (monoclonal small B cell lymphoma) is needed. To differentiate the reactive LH from the atypical forms (IgG related diseases), advanced molecular tests such as IHC and PCR (rearrangement of IG heavy chain gene (JH) and/or light chain gene, [J kappa]...

IgG4 related disease is also a potential cause of lymphoproliferative disorder, as noted in Dr. @Aruna Turaka's answer. If a patient has IgG4 disease, would you still recommend radiation therapy, or suggest other treatment?